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After obtaining my PhD in nanoelectrochemistry I joined Philips Research in Eindhoven. I initiated projects based on semiconductor nanowires for applications as LEDs, high-frequency transistors and chemical sensors. After 9 years in industry I started my research group at the Delft and Eindhoven technical University. One of the most fascinating aspects of nanowires is that we can make well-known materials with different crystal structures. In addition, new materials combinations can be realized. This materials flexibility allows designing new types of quantum structures, which are impossible in the bulk. Recently we have discovered Majorana fermions in nanowires, opening a completely new research field and interesting applications. The great challenge ahead now is to manipulate these states to demonstrate their special nature and their possible use as carrier of quantum information for quantum computing. For braiding of Majorana’s we do not only need ultra high quality material, but also perfect control of the nanowires surfaces and interfaces. Therefore, we are building an ultra-high vacuum cluster tool to fabricate complex bottom-up grown nanowires integrated with superconductors and surface passivation shells. It is very exciting to be part of such a large and ambitious project in which material science and quantum transport are closely interconnected.